Chau Hwang Lee
Dr. Chau-Hwang Lee is an associate research fellow in the Research Center for Applied Sciences, Academia Sinica, Taiwan (http://www.rcas.sinica.edu.tw/index-e.html
) and the supervisor of his laboratory which is concerned with the futuristic sounding topic of nanobiotechnology. This exciting field promises applications for medicine, biophotonics and bio-imaging. Recently he has been studying cell membrane topography as well as filopodium activities using a wide-field optical profiling technique. His main goal in imaging is to achieve sub-50 nm resolution in three dimensions with or without labeling. He looks forward to improved computational speeds in Huygens. He also hopes that the Huygens software can further improve the resolution of super-resolution structured illumination microscopy.Fig 1: "Label-free" observation of asymmetric growth of cancer-cell filopodia. The image contrast is from the topographic variations of the filopodia, rather than fluorescent labeling. The left panel shows the case before the establishment of a concentration gradient of epidermal growth factor (EGF) around a lung cancer cell. The right panel shows the same cell after the establishment of the EGF concentration gradient. The concentration gradient of EGF was established in a micro-cell-cultrue chip.
Image Source:
Ts i- Hsuan Hsu, Meng - Hua Yen, We i- Yu Liao, Ji - Yen Cheng and Chau - Hwang Lee. Label-free quantification of asymmetric cancer-cell filopodium activities in a multi-gradient chip. www.rsc.org/loc
| Lab on a Chip (Jan 15, 2009)